Vitamin C Injections
W8MD's Vitamin C Injections
W8MD Weight Loss, Sleep & Aesthethc Centers is now pleased to offer the popular vitamin C injections both intramuscular and intravenous forms at regular dose and high dose forms based on the patient’s unique situation.
What is Vitamin C?
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Vitamin C plays an important role in tissue repair and lack of this vitamin causes scurvy. Vitamin C is an essential nutrient involved in the repair of tissue and the enzymatic production of certain neurotransmitters. It is required for the functioning of several enzymes and is important for immune system function.
What is Vitamin C?
Also called Ascorbic acid, vitamin C, is a water-soluble vitamin found in many citrus and other fruits and vegetables such as green peppers.
Vitamin C or Ascorbic acid is a free radical, an antioxidant scavenger, and plays a major role in oxidation-reduction reactions. Ascorbic acid is a cofactor for enzymes involved in the biosynthesis of collagen (essential for tissue maintenance and repair), carnitine, and neurotransmitters.
Humans cannot synthesize ascorbic acid endogenously and a lack of dietary intake can lead to scurvy. Vitamin C is most frequently used as a nutritional supplement. It also is used as an adjunct treatment of idiopathic methemoglobinemia and with deferoxamine in the treatment of chronic iron toxicity.
Ascorbic acid has been used for a variety of ailments including the common cold, gum infections, acne, depression, fertility, and cancer; however, these claims have not been substantiated and vitamin C is not recommended for these purposes. Ascorbic acid was approved by the FDA in 1939.
Ascorbic acid is necessary for collagen formation (e.g., connective tissue, cartilage, tooth dentin, skin, and bone matrix) and tissue repair. It is reversibly oxidized to dehydroascorbic acid. Both forms are involved in oxidation-reduction reactions.
Vitamin C is involved in the metabolism of tyrosine, carbohydrates, norepinephrine, histamine, and phenylalanine. Other processes that require ascorbic acid include biosynthesis of corticosteroids and aldosterone, proteins, neuropeptides, and carnitine; hydroxylation of serotonin; conversion of cholesterol to bile acids; maintenance of blood vessel integrity; and cellular respiration.
Vitamin C may promote resistance to infection by the activation of leukocytes, production of interferon, and regulation of the inflammatory process.
It reduces iron from the ferric to the ferrous state in the intestine to allow absorption, is involved in the transfer of iron from plasma transferrin to liver ferritin, and regulates iron distribution and storage by preventing the oxidation of tetrahydrofolate. Ascorbic acid enhances the chelating action of deferoxamine during treatment of chronic iron toxicity (see Interactions).
Does vitamin C have antioxidant properties?
Yes. Vitamin C may have a role in the regeneration of other biological antioxidants such as glutathione and α-tocopherol to their active state.
How does vitamin C help with collagen commonly found in skin and connective tissues?
Ascorbate deficiency lowers the activity of microsomal drug-metabolizing enzymes and cytochrome P-450 electron transport. In the absence of vitamin C, impaired collagen formation occurs due to a deficiency in the hydroxylation of procollagen and collagen. Non-hydroxylated collagen is unstable, and the normal processes of tissue repair cannot occur. This results in the various features of scurvy including capillary fragility manifested as hemorrhagic processes, delayed wound healing, and bony abnormalities.
What are the Contraindications for vitamin C?
Ascorbic acid should not be ingested 48—72 hours before amine-dependent stool occult blood tests are conducted because false negatives may occur.
Chronic, excessive doses of ascorbic acid can cause an increase in its own metabolism, which can cause scurvy if normal and supplemental intake are significantly reduced or discontinued. Large doses can also increase the likelihood of oxalate stones in the urinary tract in patients with a history of nephrolithiasis, hyperoxaluria, or oxalosis.
Large IV or oral doses of ascorbic acid have caused hemolytic anemia in some patients with G6PD deficiency (glucose-6-phosphate dehydrogenase deficiency).
High doses of ascorbic acid may interfere with urinary glucose determinations using the glucose oxidase method. Patients with diabetes mellitus should be made aware of the possibility of falsely decreased glucose concentrations with these tests.
Ascorbic acid may increase the risk of iron toxicity in patients with hemochromatosis, therefore, patients with hemochromatosis should limit their intake of ascorbic acid to no more than 500 mg/day. Rarely, ingestion of large quantities of ascorbic acid have been associated with fatal cardiac arrhythmias in patients with iron overload.
Patients with anemia (e.g., sideroblastic anemia, thalassemia) may experience decreased iron absorption during high dose ascorbic acid therapy. High doses of ascorbic acid may precipitate a crisis in patients with sickle cell anemia.
Pregnancy: Ascorbic acid, vitamin C is classified as pregnancy category C. Umbilical cord blood concentrations are 2—4 times higher than those of maternal plasma levels. Adverse effects have not been reported with the normal daily intake of ascorbic acid, vitamin C within the recommended dietary daily intakes for a pregnant female. The use of ascorbic acid, vitamin C in excess of the recommended dietary allowance during normal pregnancy should be avoided unless, in the judgment of the physician, potential benefits in a specific, unique case outweigh the significant hazards involved.
Breast-feeding: Ascorbic acid, vitamin C is distributed into breast milk. Use of ascorbic acid, vitamin C within the recommended daily dietary intake for lactating women is generally recognized as safe. In mothers not taking vitamin C supplements, vitamin C in human milk in the first 6 months of lactation varied from 34—83 mg/L. In mothers taking vitamin C supplements ranging from 45 to > 1,000 mg/day, vitamin C content of human milk varied from 45—115 mg/L. Consider the benefits of breast-feeding, the risk of potential infant drug exposure, and the risk of an untreated or inadequately treated condition. If a breast-feeding infant experiences an adverse effect related to a maternally administered drug, healthcare providers are encouraged to report the adverse effect to the FDA.
Dilute in a compatible diluent prior to administration. Compatible diluents include Dextrose 5%, Dextrose 10%, 0.9% Sodium Chloride (Normal Saline or NS), 0.45% Sodium Chloride (half-Normal Saline), Lactated Ringer’s (LR), Dextrose/Saline combinations or Dextrose/LR solutions. For intermittent IV infusion: Add to a large volume of diluent and infuse slowly (manufacturer recommendations). A faster rate of infusion and less diluent have been used in clinical trials. A pharmacokinetic modeling study reported the administration of intravenous vitamin C (doses up to 1.25 gram IV) at a rate of 250 mg/min IV to healthy volunteers. Another study reported the infusion of 3 g of vitamin C infused IV over 10 minutes (rate: 300 mg/min IV) without deleterious effects on monitoring parameters such as the ECG. For continuous IV infusion: When used for the reduction of fluid resuscitation requirements in severely burned patients, a 25 mg/mL concentration was compounded in LR solution and administered at a rate of 66 mg/kg/hr.
Inject deeply into a large muscle. Aspirate prior to injection to avoid injection into a blood vessel.
Inject subcutaneously taking care not to inject intradermally.
How should I store this medicine?
Store between 32°F to 38°F (2°C to 8°C). Keep all medicines out of the reach of children. Throw away any unused medicine after the expiration date. Do not flush unused medications or pour down a sink or drain. Prepare stoppers with a suitable antiseptic wipe. Do not use unless solution is clear and seal is intact. Throw away any medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.